"A lot of awesome art work was destroyed. I don't know mate but that's just s**t. Anyhow that's how it goes."
The attack, first reported by 3AW's Ross and John, was carried out by at least 10 people and was being filmed by a drone.
Ross told listeners this morning the vandals had "obliterated all the street art".
On social media, the vandalism was met with outrage. 10 News journalist Candice Wyatt called it "vandalism by faceless cowards".
The New Daily News Editor Andrea Hamblin wrote: "Sad to see some d***heads ruining Hosier Lane. What was the point?"
Melbourne City Council has been approached for comment.