"The patient had important functional alterations, such as vision and speech problems, and the risk of severe bleeding that put his life in danger," the Barcelona hospital said.
Dr Joan-Pere Barret, the head of plastic surgery and burns at Vall d'Hebron, hailed the operation as a success, saying it was, "very good, excellent ... which the patient recognises".
Unlike similar operations where a patient has had features of their face replaced, or rebuilt, the latest procedure was much more invasive. Most of the man's lower face has been reconstructed, including his neck, mouth, tongue and the back of his throat.
Speaking to Efe, the Spanish news agency, Dr Teresa Pont said it had been a long wait for a suitable donor.
The hospital said it has another potential face transplant patient, who is awaiting a donor.
In April 2010, the Vall d'Hebron carried out the first successful face transplant operation on a patient known as "Oscar". The hospital said yesterday "Oscar" is now living, "a normal life".
- Independent