Local news service 1010 WINS reports sources as saying the shooting may be gang-related.
Initial police statements issued about 8pm local time reported they had mobilised a 'Level 1' response after reports of people having been shot, with the status of the gunman unclear.
An early 'city wide" alert was issued to hospital trauma teams, but reports indicate all wounded have so far been taken to Harlem Hospital.
Multiple ambulances have reportedly swarmed the scene.