The first illuminated advert, for French mineral water Perrier, appeared in Piccadilly Circus in 1908.
During World War Two from 1939 to 1945, the lights were off as part of a general blackout to stop German bombers identifying targets from the air.
After being constantly on since 1949, barring power cuts and temporary switch- offs for the funerals of Winston Churchill in 1965 and Princess Diana in 1997, this will be the first time the junction will be dark for an extended period.
"This is a huge day for Piccadilly Lights and though it will be a strange feeling to see them go dark, we're incredibly excited about their future," said Vasiliki Arvaniti of Land Securities that owns the site.
- AAP