The blast appears to have affected a dance studio and Chinese restaurant. The Mirrorreports 15 people were injured inside the restaurant alone
Many of the casualties are believed to have come from these premises.
Witnesses report wounded being walked and wheel to ambulances amid the rubble.
The explosion shook the ground and sent a huge plume of smoke and dust into the sky.
Police say the blast has disrupted the rail line between Birkenhead Central and Ellesmere Port/Chester. All services have been halted.
The member of parliament representing Wirral South, Alison McGovern, has tweeted: "Am on the scene in New Ferry. A very serious situation. Please stay away if you can, let emergency services do their job."
More to come.