Ms Lewinsky claimed she had turned down US$10 million in offers because it "didn't feel like the right thing to do".
Commercial ventures over the years have never taken off.
Responding to a recently disclosed 1998 conversation between Mrs Clinton and a confidante, in which the former First Lady described Ms Lewinsky as a "narcissistic loony toon", she said if that were "the worst thing she said, I should be so lucky".
Mrs Clinton had insisted the sex between Mr Clinton and the then-21-year-old had no "real meaning" and said she had not been "sensitive enough" to her husband's emotional state.
In an essay for Vanity Fair, Ms Lewinsky writes: "Hillary Clinton wanted it on record that she was lashing out at her husband's mistress. She may have faulted her husband for being inappropriate, but I find her impulse to blame the Woman - not only me, but herself - troubling."
Ms Lewinsky said she believed Mrs Clinton "blamed herself for her husband's affair [by being emotionally neglectful] and seemed to forgive him".
The renewed focus on Mr Clinton's past infidelities will be welcomed by some of his wife's political opponents as they look for ways to derail her potential 2016 bid for the White House.
Rand Paul, a Republican senator likely to run for president, has recently taken to describing Mr Clinton as "a sexual predator".
However, despite his affair and impeachment by Congress, Mr Clinton remains one of the most popular public figures in America while Mrs Clinton is the overwhelming frontrunner to be the Democrats' next presidential candidate.