"For me, I'm just trying to keep my head down, not listen to the noise and just work really hard to make a positive impact on the lives of many people," she said.
"I mean, if you want to at the end of the day, if you want to think about difficult, it's the factory worker who has been laid off. Difficult is, you know, the mother who has lost a child to opioid abuse."
She also said her father felt "very vindicated" and "optimistic" after former FBI director James Comey's testimony before Congress.
President Trump blasted the ex-FBI director after his appearance, calling him "very cowardly" as it emerged Trump reportedly bottled out of a UK state visit over fears of mass protests.
Donald Trump attacked Comey in a Sunday morning tweet after the ex-FBI director gave evidence to the US Senate Intelligence Committee last week suggesting Trump had tried to pressure him to stop an investigation into his former National Security adviser Michael Flynn.
Speaking on her recent trip to Israel, Ivanka Trump said it was an "unbelievable" experience.
"I feel blessed and privileged to have been there," she said.
"It was deeply personal for me, as you know standing at the Western Wall in a moment of privacy because it was really just us. It was beyond special."