At an appearance with the visiting Belgian foreign minister, Netanyahu said: "Our common goal, that of the U.S., Europe, China and Russia is to prevent Iran from developing a military nuclear capability."
He later said that a break in the world powers' talks with Iran gave time to achieve a "much better deal."
Dan Shapiro, the U.S. ambassador to Israel, played down talk of a crisis in relations, saying the public disagreement reflected the deep ties between the countries.
"The prime minister and the secretary have known each other for 30 years. They are good friends. They speak very openly with one another," he told Channel 10 TV. "And that's a good thing."