"An event like this, there are a number of Aboriginal communities around there and they have experienced strong shaking," Dr Jepsen said.
"We've heard from them, people have felt strong shaking, but we haven't heard of any damage yet, but there is that possibility."
There have been several aftershocks since the earthquake.
Friday's earthquake followed two quakes in the area in the past week.
The first, on March 16, measured 4.3 magnitude and the second on March 20 was 3.8 magnitude.
Friday's 6.1 magnitude earthquake is Australia's biggest since a quake measuring 6.3 was recorded off Collier Bay on West Australia's far north coast in 1997.
"This (Ernabella) earthquake would have been felt in Yulara (near Uluru), only weakly in Alice Springs and maybe as far as Coober Pedy," Dr Jepsen said.
South Australia Police said no injuries or damage had been reported.
Dr Jepsen said the region's earthquakes are caused by the release of stress from the earth's crust, built up as the Indian-Australian tectonic plate moves, squeezing South Australia sideways by about 0.1 millimetre each year.
He said on average there are about 200 earthquakes of magnitude 3.0 or more in Australia each year and one earthquake above magnitude 5.5 about every two years.
The 1989 earthquake in Newcastle, NSW that killed 13 people was a 5.6 magnitude event and the 2011 Christchurch earthquake that killed 185 people in New Zealand was 6.3 magnitude.
Australia's largest-ever recorded earthquake was in 1941 in Meeberrie, in central-west West Australia, with a magnitude of 7.3, but there were no fatalities.
AAP kn/tab/jsh
-AAP
