The coalition also said that one of its service members died of a non-battle related injury in the south. It provided no other details.
The two deaths bring the total among foreign forces to 128 so far this year, of which 98 are from the United States.
Earlier, and Afghan official said a NATO strike in the country's east killed five civilians, but the U.S.-led coalition said that it targeted insurgents and that its initial reports indicate no civilian casualties.
Lt. Col. Will Griffin, a spokesman for the coalition, said that the late Friday attack in Nangarhar province, near an airport used by NATO forces, was dealt with using a "precision coordinated strike."
Provincial spokesman Ahmad Zia Abdulzai said the strike killed five civilians. He did not provide any more details about the circumstances.
Afghan and NATO officials regularly differ as to whether civilians have been hit in attacks. Afghan President Hamid Karzai has made denunciations of reported civilian deaths in airstrikes a pillar of his political strategy.
Insurgents have increased attacks in recent months as they intensify a campaign to regain territory as foreign forces drawdown ahead of a full withdrawal at the end of 2014.