News 4-Fox 11's Ben Margiott reported hearing six shots fired since he arrived on scene.
He said he reported heard four shots in quick succession followed by three individual shots at longer intervals.
Police have advised people to avoid the area.
According to the Reno Gazette Journal, dozens of police cars, ambulances and SWAT vehicles have surrounded the Montage Reno complex.
The first reports of the shooting were made around 7.30pm local time (2.30pm AEDT).
There were no immediate reports of injuries.
One witness told the Reno Gazette he was reminded of October's mass shooting in Las Vegs when he heard the gunshots.
"When you heard it's coming from above it reminds you of the guy shooting from Mandalay Bay ... it's scary you know? This is the same kind of town," Mike Pavicich said.
On October 3, 64-year-old Nevada resident Stephen Paddock fired bullets down on the Route 91 Harvest Festival from his room on the 32nd floor of the Mandalay Bay resort and casino in Las Vegas.
Paddock killed 57 people and injured 546 others, making it the worst mass shooting in American history.
More to come.