"McDo", as the French call it, has 1,300 outlets in France and has attracted new customers by "Frenchifying" its range, offering products such as the McBaguette and the Alpine burger.
The vogue for burgers is a far cry from the days when Jose Bove, a French farmer and antiglobalisation campaigner, was sent to prison with his comrades for destroying a McDonald's in the southern town of Millau in 1999.
The campaigners behind Wednesday's march have set up a Facebook page, which so far has garnered 4,000 "likes", to persuade the local authorities to let work resume on the restaurant.
France is the second-biggest consumer of Big Macs outside the US. Photo / NZ Herald
However, that outcome appears far from certain.
Officials say work should never have been started in the first place as the fast food outlet was being constructed in a zone earmarked for industrial and not commercial activities.