A media release from Victoria Police confirmed a man, woman and eight-year-old boy were taken to hospital as a result of the blaze.
Of the injuries, the man – a firefighter – has been taken to hospital with serious smoke-related injuries, a woman is being treated for smoke inhalation and the child has been taken to hospital with minor injuries.
The statement also confirmed that a 45-year-old man, a 38-year-old woman, and an eight-year-old boy were able to escape the fire.
It is currently unknown how the tragic fire occurred, however, police are investigating its origins.
Two boys and two girls between the ages of 10 and one perished in the fire. Photo / David Crosling-NCA
A spokesman for the police said the arson explosives squad were attending the scene, although it's unknown whether the cause was suspicious or not.
'Very tragic circumstances'
David Clancy, a Commander from Country Fire Authority, said that by the time fire crews had arrived, the blaze had already spread through the house, with firefighters unable to conduct an internal exam.
The collapsed roof also impeded access to the home, Clancy said.
"It impeded access (and) made it too dangerous for firefighters to get in," he said.
"These were particularly very tragic circumstances with four young children who perished in the fire."
A Lieutenant at the Werribee Fire Brigade, Damien Molloy, said the collapsed roof and the intensity of the fire made it difficult for crews to initially access the home.
"The distress of the parents and the eight year old (also made it) very difficult to get accurate information early on to be able to focus our search areas initially," said Molloy.
By the time emergency services were on the scene, Molloy said it was "way beyond" anything a neighbour could have done to help extinguish the flames.
Once firefighters arrived on the scene they were faced with a "compromised" structure and falling tiles from the roof, he said.
