The terror group is now losing the battle across the Middle East, the US led-coalition said this week.
"ISIS is losing on all fronts, and they are losing their grip on their few remaining strongholds in both Iraq and Syria," Army Col. Ryan Dillon.
The coalition and its partners on the ground - the Iraqi security forces and the Syrian Democratic Forces - remain committed to defeating the enemy, he said.
"But make no mistake," he added, "we fully expect fierce fighting in the days ahead.
'And while these terrorists remain a dangerous and desperate enemy, our ISF and SDF partners have proven they are up to the task.'
Iraqi forces have made significant progress in the fight, Dillon said.
'Our Iraqi partners have fought a long, bloody war and have sacrificed a great deal to liberate their people and clear terrorists from cities and villages,' he told reporters.
More than 26,000 square miles in Iraq have been cleared and more than four million people are now free from ISIS control, the colonel said.
'ISIS is on the run, and we must remain focused on delivering a decisive defeat in their few remaining holdouts in Iraq,' he added.
The Syrian Democratic Forces have made steady gains in liberating Raqqa, Dillon said.
In total, across Syria, about two million people are no longer under ISIS control, and the regime has been pushed out of more than 27,000 square miles of land.