When the bees notice any fast movements from the spider, they attack and will continue "as long as they sense any movements of the enemy".
"The bee venom paralyses the spider within seconds but the bees do not want to stop. More and more bees are coming to help," the clip continues.
"The spider is completely destroyed but some bees want to make sure that the enemy is not going to come back and bite."
Mr Man, who sells honey and bees from his online company, Fast Bees, has shared a number of incredible videos on his YouTube page, including his bees taking on a praying mantis.
His latest bees v spider video racked up almost a million hits in less than a week.