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Home / World

Covid 19 Delta outbreak: Pfizer says 'game-changer' Covid pill cut hospital, death risk by 90%

By Matthew Perrone
AP·
5 Nov, 2021 06:30 PM5 mins to read

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Since the beginning of the pandemic last year, researchers worldwide have been racing to find a pill to treat Covid-19 that can be taken at home. Image / NIAID

Since the beginning of the pandemic last year, researchers worldwide have been racing to find a pill to treat Covid-19 that can be taken at home. Image / NIAID

Pfizer says its experimental antiviral pill for Covid-19 cut rates of hospitalisation and death by nearly 90 per cent in high-risk adults, as the drugmaker joined the race for an easy-to-use medication to treat the coronavirus.

Currently most Covid-19 treatments require an IV or injection. Competitor Merck's Covid pill is already under review at the Food and Drug Administration after showing strong initial results, and on Thursday (Friday NZT) the United Kingdom became the first country to OK it.

Pfizer said on Friday it will ask the FDA and international regulators to authorise its pill as soon as possible, after independent experts recommended halting the company's study based on the strength of its results. Once Pfizer applies, the FDA could make a decision within weeks or months.

"Today's news is a real game-changer in the global efforts to halt the devastation of this pandemic," Pfizer CEO Albert Bourla said in a statement.

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"These data suggest that our oral antiviral candidate, if approved or authorised by regulatory authorities, has the potential to save patients' lives, reduce the severity of Covid-19 infections, and eliminate up to nine out of 10 hospitalisations."

Since the beginning of the pandemic last year, researchers worldwide have been racing to find a pill to treat Covid-19 that can be taken at home to ease symptoms, speed recovery and keep people out of the hospital.

Having pills to treat early Covid-19 "would be a very important advance", said Dr John Mellors, chief of infectious diseases at the University of Pittsburgh, who was not involved in the Pfizer study.

"If someone developed symptoms and tested positive we could call in a prescription to the local pharmacy as we do for many, many infectious diseases," he said.

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On Friday, Pfizer released preliminary results of its study of 775 adults. Patients who received the company's drug along with another antiviral shortly after showing Covid-19 symptoms had an 89 per cent reduction in their combined rate of hospitalisation or death after a month, compared to patients taking a dummy pill.

Pfizer says its experimental antiviral pill for Covid-19 cut rates of hospitalisation and death by nearly 90 per cent in high-risk adults.
Pfizer says its experimental antiviral pill for Covid-19 cut rates of hospitalisation and death by nearly 90 per cent in high-risk adults.

Fewer than 1 per cent of patients taking the drug needed to be hospitalised and no one died. In the comparison group, 7 per cent were hospitalised and there were seven deaths.

"We were hoping that we had something extraordinary, but it's rare that you see great drugs come through with almost 90 per cent efficacy and 100 per cent protection for death," said Dr Mikael Dolsten, Pfizer's chief scientific officer.

Study participants were unvaccinated, with mild-to-moderate Covid-19, and were considered high risk for hospitalisation due to health problems like obesity, diabetes or heart disease.

Treatment began within three to five days of initial symptoms, and lasted for five days. Patients who received the drug earlier showed slightly better results, underscoring the need for speedy testing and treatment.

Pfizer reported few details on side effects but said rates of problems were similar between the groups at about 20 per cent.

An independent group of medical experts monitoring the trial recommended stopping it early, standard procedure when interim results show such a clear benefit. The data have not yet been published for outside review, the normal process for vetting new medical research.

Top US health officials continue to stress that vaccination will remain the best way to protect against infection. But with tens of millions of adults still unvaccinated — and many more globally — effective, easy-to-use treatments will be critical to curbing future waves of infections.

The FDA has set a public meeting later this month to review Merck's pill, known as molnupiravir. The company reported in September that its drug cut rates of hospitalisation and death by 50 per cent.

Experts warned against comparing preliminary results because of differences in the studies, including where they were conducted and what types of variants were circulating.

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"It's too early to say who won the hundred-metre dash," Mellors said. "There's a big difference between 50 per cent and 90 per cent but we need to make sure the populations were comparable."

Although Merck's pill is further along in the US regulatory process, Pfizer's drug could benefit from a safety profile that is more familiar to regulators with fewer red flags.

While pregnant women were excluded from the Merck trial due to a potential risk of birth defects, Pfizer's drug did not have any similar restrictions. The Merck drug works by interfering with the coronavirus' genetic code, a novel approach to disrupting the virus.

Pfizer's drug is part of a decades-old family of antiviral drugs known as protease inhibitors, which revolutionised the treatment of HIV and hepatitis C. The drugs block a key enzyme which viruses need to multiply in the human body.

The drug was first identified during the SARS outbreak originating in Asia during 2003. Last year, company researchers decided to revive the medication and study it for Covid-19, given the similarities between the two coronaviruses.

The US has approved one other antiviral drug for Covid-19, remdesivir, and authorised three antibody therapies that help the immune system fight the virus. But they have to be given by IV or injection at hospitals or clinics, and limited supplies were strained by the last surge of the delta variant.

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Pfizer shares jumped more than 8 per cent in trading Friday morning.

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