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Home / World

Covid-19 coronavirus: Lilly antibody drug fails in study, others go on

By Marilynn Marchione
Other·
26 Oct, 2020 11:17 PM2 mins to read

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A researcher tests possible Covid-19 antibodies in a laboratory in Indianapolis. Photo / AP file

A researcher tests possible Covid-19 antibodies in a laboratory in Indianapolis. Photo / AP file

United States government officials are putting an early end to a study testing an Eli Lilly antibody drug for people hospitalised with Covid-19 because it doesn't seem to be helping them.

Independent monitors had paused enrollment in the study two weeks ago because of a possible safety issue.

But today, the National Institute of Allergy and Infectious Diseases, which sponsors the study, said a closer look did not verify a safety problem but found a low chance that the drug would prove helpful for hospitalised patients.

It is a setback for one of the most promising treatment approaches for Covid-19.

US President Donald Trump received a similar experimental, two-antibody drug from Regeneron Pharmaceuticals Inc. on an emergency basis when he caught the coronavirus this month.

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Utah’s hospitals prepare to ration care as a record number of coronavirus patients flood their ICUs, via @sltrib https://t.co/QZNeQc4yal

This sad prospect of triage in times of plague is discussed in #ApollosArrow https://t.co/IpmeFcqX2v

— Nicholas A. Christakis (@NAChristakis) October 26, 2020

In a statement Lilly notes that the government is continuing a separate study testing the antibody drug in mild to moderately ill patients, to try to prevent hospitalisation and severe illness. The company also is continuing its own studies testing the drug, which is being developed with the Canadian company AbCellera.

Antibodies are proteins the body makes when an infection occurs; they attach to a virus and help it be eliminated. The experimental drugs are concentrated versions of one or two specific antibodies that worked best against the coronavirus in lab and animal tests.

Lilly and Regeneron have asked the US Food and Drug Administration to grant emergency use authorisation for their drugs for Covid-19 while late-stage studies continue.

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Lilly says its request is based on other results suggesting the drug helps patients who are not hospitalised, and that it will continue to seek the FDA's permission for emergency use.

- AP

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