Met both by loud cheers and sporadic heckling, Clinton explained that, while there is still no vaccine to prevent HIV infection or cure for Aids, the development of anti-retroviral drugs means that the world can now aim to stop HIV becoming Aids in patients everywhere and thereby also stem the pandemic's spread.
An "Aids-free generation", her declared goal, means a world, she said, where virtually no child will be born with the HIV virus, where "as children and teenagers become adults, they will be at a significantly lower risk of becoming infected than they would be today no matter where they are living", and where anyone who has the virus will have full access to drugs that keep them healthy and will stop them from transmitting the disease.
Yet some will remain sceptical of Clinton's oratory. Under pressure to deal with the deficit, President Barack Obama has proposed cuts in the largest US programme for Aids in the 2013 budget.
"The US Government's commitment to turn around the epidemic is good news," Sharonann Lynch of Doctors without Borders said. "But all donors need to reverse their [freeze in] funding for global HIV/Aids so we can reach the one in two people in urgent need of treatment who still do not have access."
Michel Sidibe, the chief of UNAids, reminded the conference that, while the world spent US$16.8 billion ($21.2 billion) fighting Aids in poor countries, this was still US$7 billion a year short of the amount needed to double the 8 million people getting life-saving drugs by 2015.
"This gap is killing people. My friends, the end of Aids is not free. It is not too expensive. It is priceless."
- Independent