A manager at Massachusetts-based Union Tour Express said he had heard that one of the company's buses was involved in an accident, but did not have any further information.
A truck driver who passed by shortly after the crash said he saw people standing outside the bus holding bloody noses and some appeared to have other facial injuries. The bus was sitting in the ditch, up against some rocks, he said.
The Ornge air ambulance service said at least one person was flown for treatment in Ottawa, which is about 88km from the accident scene.
Brockville General Hospital in Prescott, near the crash, said it received five patients who all required critical care and said one other patient was sent to a hospital in Kingston, Ontario, by air ambulance.
"All of the people that we have received are all Mandarin speaking," spokeswoman Abby McIntyre said.
McIntyre said other people injured in the crash were believed to be "walking wounded" who were taken to other hospitals.
- AP