The gunmen
There may be up to three heavily armed gunmen, reports say. The fire department said the shooters were possibly wearing body armour. They were seen in military clothing and wearing black ski masks.
A witness told CNN the suspects fled in a black SUV.
The scene
The Inland Regional Centre provides social services to people with developmental disabilities.
It employs nearly 670 staff at its facilities in San Bernardino and Riverside counties, helping more than 30,200 people. It is unclear how many people were at the facility at the time of the shooting.
The shooting was centred around a building that houses at least 25 employees as well as a library and conference center.
Reports of possible bomb
Officers at the scene were heard referring to suspicious device as an "IED" - improvised explosive device. First responders were told to keep their distance from the south building.
A man told CNN police were checking the scene for the possibility of a bomb.