The bear stepped onto a snowboarder's board while he filmed and posted the encounter on Instagram.
That bear, now 3 and named Benji, was relocated to a facility run the San Diego Humane Society, where it is receiving veterinary care.
Another similarly affected young bear showed up at a utility plant in Pollock Pines, El Dorado County, last month.
The bear showed little fear and ignored yelling and clapping aimed at shooing it away.
It then moved into a residential back garden and local people began feeding it with apples and strawberries.
A spokesman for the CDFW said: "At one point, the bear jumped into a housekeeper's open car trunk, prompting attempts to approach it and pet it."
Wildlife officials who went to visit the bear said it was displaying "dog-like" behaviour.
It sat on a back yard patio, picking up an apple and eating it in front of them. Local residents said they had become attached to it.
The CDFW spokesman said: "Physically and mentally, the bear just didn't seem quite right, walking oddly, dull and not responsive like a normal bear should be."
It was taken to a laboratory where veterinarians could observe the animal.
They found it had intermittent head tremors and a tilted head, indicating neurological abnormalities.
The bear was also only one quarter of the weight of an average black bear of its age.
It was eventually euthanised and a post-mortem examination was carried out.
Scientists found encephalitis, an inflammation of the brain usually caused by a virus - the fourth such recent case in the area.
Dr Brandon Munk, a CDFW vet, said: "At this point, we don't know what causes the encephalitis so we don't know what, if any, health risks these bears might pose to other animals."
Young black bears with the condition were previously identified in neighbouring Nevada.
The Nevada Department of Wildlife said there had been a growing number of encounters in the forested Tahoe Basin area, between humans and bears displaying neurological abnormalities.
Vets and biologists from the two states' wildlife agencies met this month to assess the problem.
They have discovered five new viruses while examining the affected bears, but don't know if any of those was responsible.
California's black bear population has tripled over the last four decades, and is now up to 40,000.
Bears have become less inhibited around people, and wandering into gardens and homes looking for food has become more common.
Their proximity to humans has also raised fears of a virus jumping species.
However, Jamie Sherman, a University of California veterinarian, told the Sacramento Bee newspaper: "The viruses that they detected in these bears were not ones particularly known to affect humans."
