Jacqueline claims that she was allowed to get back on the plane after she found her medically prescribed eczema cream.
But despite being allowed to fly, she said the reactions from staff and the "medical discrimination" she faced meant that those who don't carry "proof" of their condition could face a different outcome.
The video, which has received more than 1.3 million views, received thousands of comments from those also suffering from skin conditions concerned they too will face similar situations as Jacqueline.
"As an adult with cystic acne, I have been scared and covering up out of fear," one wrote.
"People used to bully me thinking my eczema was contagious and I'm terrified it's going to happen again," another added.
"I have psoriasis … the idea of this happening in an airport … how would you suddenly provide that documentation? No one carries that," another wrote.
The World Health Organisation deemed monkeypox as a "public health emergency of international concern" on July 23.
Previously the condition, which creates a rash that can look like pimples or blisters that appears on the face, inside the mouth, and on other parts of the body, like the hands, feet, chest, is mainly transmitted from infected animals to humans.
According to US Centers for Disease Control and Prevention (CDC) data, 23,620 cases have been reported since May in 80 countries, with 73 countries that had no previous reported monkeypox cases.
News.com.au has contacted Spirit Airlines for comment.
