The exhibition will also look at the impact of the Titanic on popular culture from books to films, culminating in the new release of Titanic 3D.
Nine costumes from the film Titanic, including those worn by Kate Winslet and Leonardo DiCaprio, will be on display along with props, such as a hand mirror, a life jacket and a life ring.
The exhibition will also tell the story of the "unsinkable" Molly Brown, played by Oscar winner Kathy Bates in Titanic 3D.
The RMS Titanic, on a voyage from Southampton to New York City, sank after striking an iceberg, resulting in the loss of some 1500 lives.
IF YOU GO
The Australian National Maritime Museum, Darling Harbour, is open daily from 9.30am to 5pm.
Remembering Titanic, runs from March 29 until November 11. Entry is included with general admission to the museum: $7 adults, $3.50 child/concession, $17.50 families.
The museum is holding a series of events on the anniversary of the sinking, April 15, including children's craft activities, a Titanic-themed movie marathon featuring the 1958 classic A Night to Remember, and an evening lecture with maritime historian Peter Plowman.
A Fateful Feasts event will also be held on May 20 with gastronomy lecturer Diana Noyce discussing the food served on the ship.