A view of the proposed Hotel at MONA from the Derwent River. Photo / Fender Katsalidis Architects, AAP
Hobart has seen a tourism boom since Mr Walsh's museum opened in 2011, with new hotels also springing up in the CBD.
Mr Walsh also proposed to shift his annual MONA FOMA festival, known as MOFO, to Launceston.
Festival curator and Violent Femmes bassist Brian Ritchie said MOFO's 10-year plan "to change the culture in Hobart has come to fruition ahead of schedule".
"We'd like to embark on a new creative journey .... to make it bigger, better, more creative, more diverse and more famous," he said.
MONA co-chief executive Mark Wilsdon wants the hotel to boost interstate tourism, which accounts for almost 75 per cent of visitors.
"We expect HOMO to be attractive to large segments of the national and international business and conference markets that previously haven't turned to Tasmania due to a lack of appropriate infrastructure," Mr Wilsdon said.
Construction will take about three years and create 300 jobs, while another 120 ongoing jobs will be created at the hotel.