This year's celebrations were a stark contrast to the previous event where Williams and Novak Djokovic danced together to the tune of Night Fever by the Bee Gees.
Williams had previously been at Cafe Royal for another party hosted by British Grand Prix winner Lewis Hamilton, fresh after she forged a place in history by equalling Steffi Graf's record of 22 Grand Slam titles.
The party progressed to Drama nightclub which included a number of celebrities making an appearance. Murray was seen putting "thousands of pounds on the bar" which led to a procession of sparkler-clad champagne bottles, The Telegraph reported.
Wimbledon doubles champion Heather Watson was one fellow tennis star who was seen partying alongside Murray until dawn. Fittingly, DJ Khaled's All I Do is Win was the final song of the night, closing out the much-deserved celebrations for the 29-year-old.
Murray arrived 20 minutes late for a 10am press conference, describing the previous night's antics as "brutal".
"I had a rough, rough night last night - celebrations with the team, it was fun. It was a great night," he said.
Murray has received an affectionate display from fans calling for his knighthood after being the first British player to win Wimbledon twice.