That whirlwind second set lasted just 22 minutes, however Wickmayer showed good composure in the third to force the match into a final set tiebreaker.
Radwanska's match was also decided by a tiebreaker after a wild second set that saw the Pole streak to a 4-0 lead before the free-swinging Hampton peeled off five straight games.
Hampton had a set point serving at 5-4, however she double-faulted, handing the momentum back to Radwanska for the final time, with the Pole closing out a 7-6 7-6 victory.
"It's great to be in the final, especially in my first tournament this year," Radwanska said.
"I'm going to do everything in my power to win it."
The world No 4 will be chasing her 12th title, while Wickmayer is in pursuit of her fourth.
With her classy all-round game, Radwanska will start a strong favourite.
"She's a struggle to a lot of players," Wickmayer said.
"It's really tough playing her, especially with my game. I hit the ball really hard and she just counters. She's always there, runs really well and it's really tough to get winners to her.
"It's going to be a tough match for me to find a balance between being aggressive and not making too many mistakes. Once I find that rhythm, I think we are going to have a good match."
Semifinals
1-Agnieszka Radwanska (Poland) bt Jamie Hampton (USA) 7-6 7-6.
3-Yanina Wickmayer (Belgium) bt 8-Mona Barthel (Germany) 6-4 1-6 7-6.
