"I want to win and make a little history," she said after blitzing Russian 17th seed Ekaterina Makarova 6-1 6-3 in exactly one hour.
An open-era record sixth crown in New York would also earn the 32-year-old the first women's title hat-trick since Evert won four straight during 1975-78.
And Williams is strongly favoured to do so after dominating Wozniacki 8-1 head-to-head.
But the world No1 is full of respect for her good friend and foe, especially after being pushed in three-setters last month in both Montreal and Cincinnati.
"I definitely expect another close match," Williams said. "She really knows my game well and knows how to play. She's so consistent. I think that's one of the things that makes her really tough.
Stranded on 17 majors since last year's US Open, Williams is taking nothing for granted after crashing out before the quarter-finals at the season's first three grand slams.
But she let slip that a last-16 exit in Melbourne, second-round defeat in Paris and a third-round loss at Wimbledon were also fuelling her motivation.
"There's always - what is the word - sceptics? I don't know," the American said. "People might not believe [but] I worked really hard for Wimbledon. I was really disappointed and sad and shocked that I wasn't able to win. I worked hours, more than I worked before. Maybe it's just paying off now."
Despite her galling one-from-nine record against Williams, a more aggressive Wozniacki is confident she now has the game to upstage the top seed.
"I definitely believe that, no matter who stands on the other side of the net, I can win the match," Wozniacki said after booking her date with destiny when Peng retired while trailing 7-6 (7-1) 4-3.
"Either way, it's been a great tournament for me and I hope that I can get one more win under my belt."
- AAP