The American has won the Australian Open five times, but she's failed to come up trumps since last lifting the trophy there in 2010.
World No2 Maria Sharapova, Simona Halep, Petra Kvitova and Eugenie Bouchard are among the contenders to take home this year's crown, while Radwanska is also in with a huge chance after her strong form at the Hopman Cup.
Radwanska beat Casey Dellacqua, Williams and Heather Watson during the tournament, with her only blemish a hard-fought three-sets loss to Frenchwoman Alize Cornet.
The 25-year-old recently linked with Martina Navratilova, and she's hoping having the tennis legend on her coaching team will prove to be a pivotal step in winning her first career major. But for now, Radwanska will turn her attention to the Sydney International, where she takes on Cornet in what all are expecting to be another epic tennis encounter.
"When we play it's always three hours, so we are laughing that we will try to play less than that this time," Radwanska said.
Poland's win was their first Hopman Cup title triumph, making up for last summer's loss to France.
The tournament was hit by a glut of withdrawals on the men's side of the field, with Nick Kyrgios, Jo-Wilfried Tsonga, Jack Sock and Radek Stepanek pulling out before the start, and Matt Ebden (calf injury) lasting just one match.
Nevertheless, a total of 95,742 attended the tournament, well up on last summer's figure of 84,050.
The Hopman Cup record still stands at 104,468, which was achieved during the tournament's first appearance at Perth Arena two years ago.
- AAP