He regards his Open quarter-final, however, as his greatest test.
"For sure," Nishikori said.
"This is first quarter-final for me, so I feel I'm stepping up. But I have no pressure. I will be playing for everything ... for my life."
Nishikori has played Murray only once, an encounter he remembers well.
"He kind of destroyed me," he said.
"But I learn a lot of things from him.
"I have respect, but I am trying to beat him."
Murray, the fourth seed, is far from dismissive of the latest opponent to stand between him and the grand slam title he has come within one win of collecting at the past two Australian Opens.
"He's very good ... very deceptive," Murray said.
"For somebody that's not the tallest guy, he creates a lot of power from the back of the court.
"He deals with pace well. He can slice; he moves well.
"He was dictating all the points from the back of the court, which is difficult against someone like Tsonga."
While Nishikori endured five sets under a blazing sun to make the quarters, Murray got there on a virtual default after his opponent Mikhail Kukushkin withdrew after two sets.
Against that, Murray must contend with the pressure of being the only player among the world's top four not to have won a major.
He and Nishikori must also contend with another scorching afternoon, with Rafael Nadal and Berdych being awarded the cool of the night.
AAP