The Russian pulled off a 6-0 6-0 7-6 on John Cain Arena, with Nishioka winning just 13 points in the first two sets.
In set two, he managed only two points across six games in an embarrassing annihilation.
It’s called a “bronze set” and the tennis world was floored.
He faces American Sebastian Korda in the quarterfinals.
“First two sets, I didn’t know what was going on,” he said. “You’re going with the score, let’s say, too easy. Then Yoshi turned it around, pumped the crowd and I tried to stay focused from beginning to end.
“It’s not easy to win with this score, three sets, but I’m playing well and really happy to go through.”
However, on the women’s side of the draw, until the final match of the day between Victoria Azarenka and Zhu Lin, it was straight sets victories.
However, it was World No. 1 Iga Swiatek who was knocked out by 22nd seed and Wimbledon champion Elena Rybakina, 7th seed Coco Gauff saying goodbye at the hands of 17th seed Jelena Ostapenka and 20th seed Barbora Krejcikova out to 3rd seed Jessica Pegula.
Two-time Australian Open winner Azarenka was also shocked in the first set by World No. 87 Zhu, before recovering in the second set and finishing off the two hour and 40 minute epic 4-6 6-1 6-4.