It's a grueling, prolonged slog out on the water. The fastest recorded time was posted in 2016 by New South Wales yacht Perpetual LOYAL, which crossed the line in 1 day 13 hours 31 minutes 20 seconds.
Along the way, crews will be tested by weather conditions that can change without warning in a race that truly tests those who undertake it.
Adverse conditions have wreaked havoc on the race in the past including the 1998 race during which six sailors lost their lives and five vessels were locked away in Davy Jones' Locker.
But it's not just the weather conditions that will test the sailors. A variety of water channels also pose problems for the competitors. Get to the Derwent River at the wrong time of day and you could be struggling to make ground for hours.
In its 72 years to date, the full fleet has completed the race just twice, as over 1000 of the 5509 campaigns have ended prematurely.
For that reason, it's been dubbed one of the toughest ocean races on the planet.