The Crusaders and Highlanders have met three times previously in Super Rugby playoffs with the Crusaders winning all three encounters.
However they haven't clashed in the post season since the 2002 semifinals. They met twice during the season, Crusaders won 30-27 in Dunedin and 25-22 in Christchurch.
The Hurricanes thrashed the Brumbies 56-21 during their previous meeting in Napier in April, while the Chiefs have already travelled to Cape Town this season where they lost 34-26 to the Stormers.
The Chiefs look to have the toughest path to the final which could potentially mean two trips to South Africa. Should the Chiefs beat the Stormers this week they will then have to travel to back New Zealand to face the winner of the Crusaders and the Highlanders clash for a spot in the final.
Super Rugby quarter-finals
Friday
4-Brumbies v 5-Hurricanes, Canberra, 9.35pm
Saturday
2-Crusaders v 7-Highlanders, Christchurch, 7.35pm
Sunday
1-Lions v 8-Sharks, Johannesburg, 12.30am
3-Stormers v 6-Chiefs, Cape Town, 3am