Ready and Moore's running battle for the No.2 jersey always loomed as an intriguing Reds subplot this season and one of Stiles' biggest ongoing selection headaches.
He faces a difficult task in striking a balance between Ready's need for more minutes to fast-track his development, and keeping Moore happy and in-form ahead of Australia's international assignments later this year.
Queensland's other changes are to their second-row stocks, with Kane Douglas returned to the starting side to replace rookie Izack Rodda, who copped a head knock in his starting debut against the Crusaders and has been unable to train fully.
Lukhan Tui has been named on the bench for his first appearance of the season.
"Again, we've got a lot of quality depth in the lock position. Both Kane and Lukhan bring a lot of aggression and physicality, so they're a good fit for this game," Stiles said.
The Reds have lost their last nine matches on the road and have not fared well in South Africa in recent times, but Stiles said he was pleased with how they were shaping up.
"We're here to get results and a win at altitude against a quality team like the Lions would be a great reward for our hard work," he said.
Queensland Reds: Karmichael Hunt, Izaia Perese, Samu Kerevi, Duncan Paia'aua, Eto Nabuli, Quade Cooper, Nick Frisby, Scott Higginbotham, George Smith, Hendrik Tui, Kane Douglas, Rob Simmons, Sam Talakai, Andrew Ready, James Slipper (capt).
Reserves: Stephen Moore, Markuz Vanzati, Taniela Tupou, Lukhan Tui, Adam Korczyk, James Tuttle, Jake McIntyre, Chris Kuridrani
- AAP