In the pack, Blade Thompson gets his first start of the year at No 8, while Michael Fatialofa starts at lock ahead of Vaea Fifita.
Fifita, who suffered a head knock against the Blues, will fill a spot on the bench.
The Hurricanes go into Friday night's match looking to notch their tenth straight win, while the Reds will hope to bounce back from a thrashing at the hands of the Sunwolves in Japan last week.
It has been a tough year for the Brad Thorn-coach Australian side.
Through 14 weeks of the competition, the Reds have scored the fewest points (198) and the fewest tries (23). The Hurricanes, on the other hand, have scored the third-highest points (353) and tries (53).
Hurricanes: Jordie Barrett, Nehe Milner-Skudder, Matt Proctor, Peter Umaga-Jensen, Ben Lam, Beauden Barrett, TJ Perenara, Blade Thompson, Ardie Savea, Reed Prinsep, Sam Lousi, Michael Fatialofa, Jeff Toomaga-Allen, Ricky Riccitelli, Toby Smith. Reserves: James O'Reilly, Chris Eves, Ben May, Vaea Fifita, Brad Shields, Jamie Booth, Jackson Garden-Bachop, Julian Savea.
To get the day's top sports stories in your inbox, sign up to our newsletter here