Jason Rutledge will make his first start in front of his home crowd in Invercargill in the absence of Hore and Chris Noakes will take over at first five-eighths from Slade. Aaron Smith retains the halfback's jersey ahead of Jimmy Cowan.
The Rebels have won of their four games so far this season.
Highlanders team to play the Rebels at Rugby Park Stadium, Invercargill, on Friday (7.35pm): Ben Smith, Kade Poki, Tamati Ellison, Shaun Treeby, Hosea Gear, Chris Noakes, Aaron Smith, Nasi Manu, Adam Thomson, James Haskell, Jarrad Hoeata, Josh Bekhuis, Chris King, Jason Rutledge, Jamie Mackintosh (c). Reserves: Brayden Mitchell, Ma'afu Fia, Culum Retallick, Doug Tietjens, Jimmy Cowan, Phil Burleigh, Buxton Popoali'i.