Lock Quinten Strange will make his first start of the season, pairing up with Sam Whitelock in the second row, while Luke Romano takes a spot on the bench.
The loose forward trio will be Heiden Bedwell-Curtis, Pete Samu and Jordan Taufua, with Jed Brown having recovered from injury to take a place in the reserves.
The halves combination of Bryn Hall and Richie Mo'unga retain their places but will be working inside a new midfield pairing, with Seta Tamanivalu switching to centre and Tim Bateman starting in place of a concussed Ryan Crotty.
Crusaders team to play the Rebels in Melbourne on Saturday night:
1. Wyatt Crockett
2. Ben Funnell
3. Michael Alaalatoa
4. Quinten Strange
5. Sam Whitelock (c)
6. Heiden Bedwell-Curtis
7. Pete Samu
8. Jordan Taufua
9. Bryn Hall
10. Richie Mo'unga
11. Manasa Mataele
12. Tim Bateman
13. Seta Tamanivalu
14. Israel Dagg
15. David Havili
Reserves: Andrew Makalio, Joe Moody, Oli Jager, Luke Romano, Jed Brown, Mitchell Drummond, Mitchell Hunt, George Bridge