The Brumbies, should they make the finals as Australian conference winners, are likely to have the worst points tally of all in the top eight and Dave Rennie's men will be heavy favourites to win and head to Christchurch for a blockbuster of a semifinal.
It's not out of the question that all four New Zealand finalists will make the semifinals. Only one overseas team has beaten a Kiwi outfit - the Stormers beating the Chiefs in Cape Town - and the Kiwi derbies in particular have been several steps up in terms of intensity.
Should the Blues, currently out of the mix but still in the hunt for the Highlanders' wildcard spot, make the quarter-finals - and potentially against the Lions - they will have to travel there from Tokyo.
The Blues' final round-robin match is against the Sunwolves.
Ellis Park, the Lions' home ground, has traditionally been a tough place to play for New Zealand teams. The All Blacks have played 14 tests at the stadium between 1928 and 2015, winning five and losing nine. The All Blacks' last loss there was in 2014, a 27-25 thriller when Pat Lambie kicked a penalty to win it in the final minutes.
The All Blacks won there in their last meeting in 2015, a 27-20 victory helped by Richie McCaw's controversial lineout try, converted by Lima Sopoaga in his first test, which allowed the All Blacks to overtake the Boks from a 17-20 deficit.
Last year, the Lions lost to the Crusaders and Hurricanes at home, before beating the Crusaders in their quarter-final and Highlanders in their semifinal on home turf.
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Quarter-finalists as it stands (with seedings):
Crusaders (1) v Sharks (8) in Christchurch
Lions (2) v Highlanders (7) in Johannesburg
Stormers (3) v Hurricanes (6) in Cape Town
Brumbies (4) v Chiefs (5) in Canberra
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Lions' run-in: Waratahs (h), Kings (h), Sunwolves (h), sharks (a).
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Under Sanzaar's playoff's format, the four conference winners host a quarter-final (currently the Crusaders, Lions, Stormers and Brumbies), the next four positions are made up of the best next three Australasian conference teams (currently Chiefs, Hurricanes and Highlanders), plus a South African conference team (currently Sharks).