In the forwards, Chris King comes back into the front row replacing Ma'afu Fia, while Culum Retallick, James Haskell and Doug Tietjens all make their run-on debut for the 2012 season. In the backs, Shaun Treeby makes his return from injury at second five-eighth.
The Highlanders team to play the Brumbies at Canberra Stadium in Canberra on Saturday is:
Ben Smith, Kade Poki, Tamati Ellison, Shaun Treeby, Hosea Gear, Colin Slade, Aaron Smith, Nasi Manu, Doug Tietjens, James Haskell, Culum Retallick, Josh Bekhuis, Chris King, Andrew Hore, Jamie Mackintosh (c)
Reserves: Jason Rutledge, Bronson Murray, Nick Crosswell, Elliot Dixon, Jimmy Cowan, Chris Noakes, Buxton Popoali'i