"The Sharks are on a roll, and if there is a team you won't bet against now, it is them," said de Villiers told South Africa's Business Day.
"It will be fantastic for them if they can go on to win it. They've showed they can overcome the travelling, and it may be tough for them, but I think SA should get behind them. They have a great chance of winning it."
Bulls forwards coach Johann van Graan added: "They showed in the last two weeks that they are not influenced by public sentiment and their forwards have been playing outstanding rugby.
"With guys like Willem [Alberts] playing at lock and Bismarck [du Plessis] playing a fetching role, one could say they are playing with five loose forwards, and Ryan Kankowski has been doing well in the lineouts.
"Obviously their draining travel schedule will result in the final being an even greater test for them, but I think they have a good chance of winning," he said.
Adding to the Sharks' difficulties is the fact that the match today was officially sold out within two hours of tickets going on general sale. The vast majority of those 25,000 supporters will be cheering for the Chiefs to win their first title.
In their favour is the fact that Chiefs captain and lock Craig Clarke remains in doubt due to a knee injury suffered in last week's semifinal win over the Crusaders.