Ranger, the six-test All Black, missed last year with a serious knee injury with his return this season cut short by a nasty ankle injury.
Loose forward Jimmy Tupou is another returning from injury, after a hamstring tear kept him sidelined for half the season.
The Blues (6-6) are last in the tough New Zealand conference but ahead in the overall standings of the struggling Reds (3-9).
Umaga said playing a home game in Apia was a special occasion. "We have a significant number of our club who have heritage in Samoa, including myself, and it's a privilege for so many of our team to return home to play in front of friends and family," he said.
Sione Mafileo and a returning Alex Hodgman have been rewarded for their excellent form, joining Parsons, Tupou, Luatua and Kara Pryor in a mobile loose forward combination.
Northland pivot Sam Nock makes his first start at halfback to spark a backline where Ioane forms part of a dangerous back three with Melani Nanai and Declan O'Donnell.
Blues team
Melani Nanai, Declan O'Donnell, Rene Ranger, TJ Faiane, Rieko Ioane, Piers Francis, Sam Nock, Steven Luatua, Kara Pryor, Jimmy Tupou, Gerard Cowley- Tuioti, Patrick Tuipulotu, Sione Mafileo, James Parsons (c), Alex Hadgman.
Reserves: Hame Faiva, Sam Prattley, Ofa Tu'ungafasi, Akira Ioane, Murphy Taramai, Billy Guyton, Stephen Perofeta, Jordan Trainor.