If they don't, the competition's best attacking team, boasting 29 points per game, can rip them apart.
"Barrett's come into his own and they rely on him a lot," Reds centre Mike Harris said. "He probably passes the most, runs the most and kicks the most in their whole team.
"He's definitely a key man for them. We have a couple of things that we are going to try to do to minimise him."
Harris has the big job to lead the defensive line up from the midfield after coach Richard Graham had no hesitation in returning him from an Achilles problem, replacing Anthony Fainga'a.
Tough tackling Fainga'a has traditionally been the Reds' defensive linchpin but Kiwi-born Harris has filled the role and can provide extra ball-playing skill.
Without a win in Wellington since a memorable Athletic Park comeback in 1998, Graham is desperate for a better start after bumbling to 12-0 and 20-3 deficits against the Force and Brumbies respectively.
To that end, he's rushed aggressive prop Ben Daley back from injury to add physicality against a hard-working Hurricanes pack that fails to get the wraps of their backline.
As well as inspirational second-rower Horwill's 100th cap, the Reds need a big game from another milestone man with 50-game centre Ben Tapuai opposing Conrad Smith.
Graham revealed Tapuai had returned to the form that made him a 2012 Wallaby after improving his training ethic but still wanted him to be more assertive in attack.
-AAP