It was a clinical first-half performance which carried the Crusaders to their 25-17 win in the competitions decider at Ellis Park eight months ago.
Yet it was their finishing that let them down in the opening stanza on Monday morning (NZT), botching a handful of try-scoring chances.
Instead, Lions winger Madosh Tambwe bagged the only early points through a well- worked try.
It clicked after the break for the visitors, with All Blacks lock Whitelock powering over from close range before Goodhue benefited from a Manasa Mataele half-break and offload.
Rising centre Goodhue, who also scored in last years final, strained a hamstring as he powered across and was replaced. He is in doubt for the Crusaders' next game against the Jaguares in Buenos Aires.
The win was the fourth in succession on South African soil for the Crusaders, something the eight-time champions have never previously achieved. They have won nine of their last 10 matches against the Lions.
A Lions team featuring eight changes continue to play without the confidence that has taken them to the last two finals.
They remain top of the South African conference but look fragile, having conceded a competition-high 35 tries.
- AAP