Charlie Ngatai is another absentee, having failed to pass concussion protocols following a head knock in last weekend's loss to the Hurricanes, leaving cousins Sonny Bill Williams and Tim Nanai-Williams to occupy the midfield.
The feature of the forward pack is a slight reshuffle in the loose trio, with Michael Fitzgerald shifting to blindside flanker, Liam Messam moving to No8 and Michael Leitch dropping to the bench.
Chiefs team to play the Highlanders at Forsyth Barr Stadium in Dunedin on Saturday night:
Damian McKenzie, Bryce Heem, Tim Nanai-Williams, Sonny Bill Williams, James Lowe, Andrew Horrell, Brad Weber, Liam Messam (c), Sam Cane, Michael Fitzgerald, Brodie Retallick, Matt Symons, Ben Tameifuna, Hika Elliot, Pauliasi Manu.
Reserves: Quentin MacDonald, Siate Tokolahi, Jamie Mackintosh, Mitchell Crosswell, Michael Leitch, Kane Hammington, Marty McKenzie, Seta Tamanivalu.