The Hurricanes know the Reds are a tricky opponent.
"They've got a really good scrum," said coach Chris Boyd. "They're quite direct, quite powerful.
"They've been unlucky in a lot of their games but they're a good side and playing in Brisbane is a tough assignment, historically."
The Reds upset the Cheetahs 18-17 in Bloemfontein last weekend, which will have given them a boost.
The Hurricanes back three has a fresh look. James Marshall is at fullback, Matt Proctor will play on the right wing and Julian Savea is on the left. Veteran Cory Jane will play from the bench.
Boyd had envisaged resting a few of his All Blacks, including Jane, this week but last Saturday's loss to the Waratahs forced a rethink.
A calf injury to custodian Nehe Milner-Skudder and the loss of Jason Woodward (broken ankle) for the season, prompted another juggle, which means Jane is in in the reserves rather than taking a break.
"He's not been benched or dropped," Boyd said. "It's just to give Matty a chance to play."
Woodward was injured playing club rugby last weekend and has been replaced in the squad by exciting youngster Sam McNicol.
Boyd knows he has to manage resting a few more of his All Blacks, but said it was unlikely many would get a break during the next few weeks.
The Hurricanes could go close to locking up a playoff spot if they have more wins during the next month and they may be able to target a game later in the season for which several players can be given the day off.