Saturday's match will also mark a special occasion for skipper Conrad Smith who will play his 100th game for the franchise.
"When I played that first game in 2004, very few would have guessed I'd reach this point. It's such an honour and I treasure every opportunity I get to wear the swirl and represent the team I love,'' the 32-year-old said.
The Hurricanes have opened their season with three losses and are in desperate need of a win to get their campaign on track.
The Cheetahs have made a handful of changes to their side who lost 43-33 to the Reds last week.
Hurricanes: James Marshall, Alapati Leiua, Conrad Smith (captain), Hadleigh Parkes, Julian Savea, Beauden Barrett, Chris Smylie, Blade Thomson, Ardie Savea, Faifili Levave, Mark Reddish, Jeremy Thrush, Jeffery Toomaga-Allen, Dane Coles, Ben Franks. Reserves: Motu Matu'u, Chris Eves, John Schwalger, James Broadhurst, Jack Lam, TJ Perenara, Matt Proctor, Marty Banks.
Cheetahs: Willie le Roux, Cornal Hendricks, Johann Sadie, Francois Venter, Raymond Rhule, Johan Goosen, Sarel Pretorius, Philip van der Walt, Lappies Labuschagne, Boom Prinsloo, Francois Uys, Lood de Jager, Nicolaas van Dyk, Adriaan Strauss (captain), Caylib Oosthuizen. Reserves: Ryno Barnes, Trevor Nyakane, Rossouw de Klerk, Andries Ferreira, Jean Cook, Shaun Venter, Elgar Watts, Hennie Daniller