Welsh halfback Leigh Halfpenny damaged knee ligaments during Wales' final warm-up game against Italy. Photo / AP.
The Rugby World Cup has not yet reached the midway point of the pool stage but squads are already being stretched by injuries.
While Wales are leading the way with a whole host of issues, they are by no means the only nation having to dig deep into their resources.
Here, we take a look at the players who have seen their World Cup dreams crushed by untimely injuries.
WALES
Leigh Halfpenny: The full-back and prolific points-scorer damaged knee ligaments during Wales' final warm-up game against Italy.
Eli Walker: Called into Wales' squad as a replacement for Halfpenny, but then suffered a hamstring injury and was released seven days later.
Rhys Webb: Wales' in-form scrum-half suffered a serious foot injury in the first half against Italy. Battling to play again this season.
Cory Allen: Wales centre scored three tries against opening opponents Uruguay, then suffered a serious hamstring injury.
Scott Williams: Carried off after suffering a serious knee injury during Wales' Pool A victory over England at Twickenham.
Hallam Amos: Damaged shoulder during the England game as Wales' injury woes continued at an alarming rate.
ITALY
Andrea Masi: The Wasps back damaged his Achilles during the opening pool game against France.
Luca Morisi: Suffered a knee injury and went off early during Italy's warm-up clash against Wales, ending his participation in the competition.
Angelo Esposito:
Damaged his shoulder before the tournament started and was ruled out of World Cup contention.
CANADA
Connor Braid: The versatile back suffered a broken jaw during Canada's Pool D encounter against Italy in Leeds, ruling him out of the tournament.
Jason Marshall: Marshall was an early injury casualty for Canada, with his place being taken by Jake Ilnicki.
Liam Underwood: Underwood was hurt during Canada's opening game against Ireland in Cardiff and replaced by James Pritchard.
AUSTRALIA
Will Skelton: Suffered a pectoral muscle injury during Australia's 65-3 victory over Uruguay at Villa Park, ending his tournament.
Wycliff Palu: Damaged a hamstring in the same game as Skelton was hurt, which brought a full stop to his World Cup ambitions.
FIJI
Isei Colati: The powerful prop suffered a knee injury during training in Swansea and he was ruled out of the tournament.
Waisea Nayacalevu: Wing Nayacalevu suffered a World Cup knockout blow when he damaged his knee during the Pool A game against Australia.
ENGLAND
Billy Vunipola: The number eight suffered a knee ligament strain in the defeat against Wales and a scan revealed he will be sidelined for six weeks.
FRANCE
Yoann Huget: One of France's most potent attackers suffered a knee injury in the game against Italy, ending his interest in the tournament.
SCOTLAND
Stuart McInally: The Edinburgh hooker featured for the Scots against Italy in Turin last month but a neck injury cost him his place in Vern Cotter's travelling party to England.
Grant Gilchrist: The Scotland lock suffered a groin injury in Sunday's 39-16 win over the United States and will not be back in time to play a further part in the tournament.
SOUTH AFRICA
Jean de Villiers: The Springboks skipper, who has endured a terrible time with injuries in recent months, suffered a tournament-ending broken jaw in the pool game against Samoa, and then retired from Test rugby.
SAMOA
Logovi'I Mulipola: The Leicester prop was named in Samoa's World Cup squad, but he was then ruled out through injury and ex-Saracens forward Census Johnston replaced him.
UNITED STATES
Scott LaValla: LaValla suffered an injury during pre-tournament training and was replaced by Matt Trouville.
ARGENTINA
Matias Diaz: Diaz sustained a World Cup-ending injury just hours after the Pumas' squad was announced. His misfortune meant a call-up for fellow prop Juan Pablo Orlandi.
-DAILY MAIL