Shipperley enjoyed a breakout Super Rugby campaign with the Reds this season when the 21-year-old played every minute of all 17 matches and scored eight tries.
Waratahs prop Paddy Ryan and Queensland centre Ben Tapuai also join the squad, while Queensland back-rower Jake Schatz wasn't considered due to a shoulder injury.
The Wallabies will announce their 22-man squad for the Test at Patersons Stadium on Tuesday as they aim to repeat their World Cup quarter-final victory over the Springboks.
Australia will be also be looking to retain the Nelson Mandela Challenge Plate which they've held since a 41-39 win over South Africa at Bloemfontein in 2010.
Wallabies squad:
Adam Ashley-Cooper, Kurtley Beale, Digby Ioane, Dominic Shipperley, Nick Cummins, Rob Horne, Ben Tapuai, Anthony Faingaa, Mike Harris, Pat McCabe, Berrick Barnes, Quade Cooper, Nick Phipps, Will Genia (capt), Scott Higginbotham, Radike Samo, Michael Hooper, Liam Gill, Dave Dennis, Rob Simmons, Nathan Sharpe, Kane Douglas, Caderyn Neville, Sitaleki Timani, Ben Alexander, Paddy Ryan, James Slipper, Benn Robinson, Saia Faingaa, Stephen Moore, Tatafu Polota Nau.
- AAP
-AAP