Flanker Jack Dempsey is in line to add to his first test appearance in June after being named on the bench ahead of Lopeti Timani.
Australia has lost its first two tests in the Rugby Championship this season, going down 54-34 and 35-29 to New Zealand while South Africa is unbeaten after back-to-back wins over Argentina.
Cheika has already sprung surprises during the Rugby Championship. He named rugby league convert Curtis Rona to make his test debut against New Zealand last month as a winger, although Rona had only played a few minutes in that role in Super Rugby.
South Africa was expected to name its team later Thursday.
Australia: Israel Folau, Henry Speight, Tevita Kuridrani, Kurtley Beale, Reece Hodge, Bernard Foley, Will Genia; Sean McMahon, Michael Hooper, Ned Hanigan, Adam Coleman, Rory Arnold, Sekope Kepu, Tatafu Polota-Nau, Scott Sio.
Reserves: Jordan Uelese, Tom Robertson, Allan Alaalatoa, Rob Simmons, Jack Dempsey, Nick Phipps, Samu Kerevi, Curtis Rona.