A full-strength Eagles line-up would have provided a stern challenge for the Colin Cooper-coached Maori squad.
But Mitchell will now be without the likes of powerhouse lock Samu Manoa who is on a $NZ1m plus a year deal with star-studded French Top 14 club Toulon where Ma'a Nonu is also based.
Manoa was described in 2014 by ESPNscrum as "perhaps the finest No.8 playing the game in the northern hemisphere" but his career with the Eagles has been limited to 15 caps due to his European club career.
Others who will be missing include former captain Todd Clever who is with the Newcastle Falcons in the English premiership, No. 8 Cam Dolan and outside back Blaine Scully who are both with Cardiff Blues and Rugby World Cup first five AJ MacGinty who was signed by English club Sale this year from Irish club Connacht.
The veteran Clever has played professionally in Japan, New Zealand and South Africa and now England. He missed the last Rugby World Cup due to dispute with the then national coach but might have been up for a recall under Mitchell.
As many as a dozen leading American players are unavailable to Mitchell.
The Maori will face the Eagles at Toyota Park as the first leg of a historical rugby double-header in Chicago. The day after the Maori-Eagles clash at Toyota Park, the All Blacks will face 2015 Six Nations champions Ireland at iconic Soldier Field, the home of the Chicago Bears NFL team.