Hooker Bongi Mbonambi returns from injury for a place among the reserves.
Defending champion New Zealand and South Africa are tied on 14 points, with the All Blacks topping the standings on points difference.
New Zealand host Australia earlier on Saturday, meaning the Springboks will know the result of that game and what they need to do against the Pumas to win the title.
Australia and Argentina also have outside chances of winning the tournament.
South Africa: Willie le Roux, Canan Moodie, Jesse Kriel, Damian de Allende, Makazole Mapimpi, Frans Steyn, Jaden Hendrikse, Jasper Wiese, Pieter-Steph du Toit, Siya Kolisi (c), Lood de Jager, Eben Etzebeth, Frans Malherbe, Malcolm Marx, Steven Kitshoff.
Reserves: Bongi Mbonambi, Ox Nche, Vincent Koch, Franco Mostert, Duane Vermeulen, Kwagga Smith, Faf de Klerk, Kurt-Lee Arendse.